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Kinetic Investigations To Enable Development of a Robust Radical Benzylic Bromination for Commercial Manufacturing of AMG 423 Dihydrochloride Hydrate

During development of a radical benzylic bromination, observation of polymerized byproducts and variation in isolated yields warranted an in-depth mechanistic investigation to ensure process understanding and robustness.

Read how in-situ kinetic studies using multinuclear CryoFree NMR spectroscopy with an HTS-110 magnet leads to an enhancement in manufacturing yield of approximately 15% in the full article at ACSPublications.

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